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International Conference on Cheminformatics and Computational Chemical Biology

Brisbane, Australia

Andrea Altieria

aEDASA Scientific srls., Italy

Title: 2-Phenyl-4,5,6,7-Tetrahydro-1H-indole Fragments as a Novel Anti-Hepatitis C Virus Research Tools

Biography

Biography: Andrea Altieria

Abstract

Although all-oral direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) treatment is now a reality, today’s HCV drugs are expensive, and more affordable drugs are still urgently needed. In this work, we report the identification of the 2-phenyl-4,5,6,7-tetrahydro-1H-indole fragments that inhibits cellular replication of HCV genotype 1b and 2a subgenomic replicons.. The most potent fragment displayed EC50 values of 7.9 and 2.6 µM in genotype 1b and 2a, respectively. Biochemical assays showed that this fragment (39) had no effect on HCV NS5B polymerase, NS3 helicase, IRES mediated translation and selected host factors.