Cheminformatics and Computational Chemical Biology

Biography

Biography: Rhazi Naima

Abstract

In order to increase the yield extraction of condensed tannins, to preserve the quality and the reactivity of phenolic compounds extracted and also to find new environmentally-friendly extraction conditions a response surface methodology (RSM) was used. This methodology was an effective and powerful statistical method to optimize extraction process while giving a maximum of information, reducing number of experimental trials required and giving the best precision of the results calculated with the established model. The development of the experimental design was described by Rhazi et al., (2015 a). RSM was used to identify the significant factors to improve yield extraction, to reduce solvent proportion and time extraction. It permit to model extraction conditions and also to determine optimal conditions, which give higher yield of condensed tannins using lower proprtion of solvent and shorter time extraction. The present study aims to develop green extraction process of phenolic compounds extracted from Moroccan barks of Acacia mollissima using a traditional maceration. The parameters studies in this research are time extraction (X1), methanol proportion (X2) and bark ages (X3). The result of RSM showed a good agreement between the predicted and experimental values (R2= 0.98; 0.97 and 0.99 respectively for the extracts).